Ferroptosis is a type of programmed cell death resulting from iron overload-dependent lipid peroxidation, and could be promoted by activating transcription factor 3 (ATF3).SIRT1 is an enzyme accounting for removing acetylated lysine residues from target proteins by consuming NAD+, but its role remains elusive in ferroptosis and activating ATF3.In t
The dynamic performance of three slab ballastless tracks in the China Railway Track System (CRTS), which is supported by a simply supported box girder under various train loads, were comprehensively investigated with refined rigid-flexible coupled models.A refined rigid-flexible coupled model of vehicle-multi layer track-bridge system was developed
Avelumab first-line maintenance (1LM) is approved for patients with locally advanced or metastatic urothelial carcinoma (la/mUC) who do not have disease progression after platinum-based chemotherapy (PBC).This retrospective study describes real-world treatment patterns and clinical outcomes in patients with la/mUC who initiated first-line (1L) syst
BackgroundChlamydiaceae are a family of obligate intracellular pathogens causing a wide range of diseases in animals and humans, and facing unique evolutionary constraints not encountered by free-living prokaryotes.To investigate genomic aspects of infection, virulence and host preference we Washbag have sequenced Chlamydia psittaci, the pathogenic